Office of Dietary Supplements. eHealthMe is studying from 581 Ashwagandha users for its effectiveness, alternative drugs and more. Take extra care if you are taking iron supplements. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. Some products may not mix well with other drugs or natural products. 8-19-2005;334(1):276-287. More questions? Does dextromethorphan interact with my other drugs? Concerns Taking Wellbutrin For Panic Attacks, Questions About A High Dosage Of Amoxicillin For A Child With Strep Throat. Its effects on arterial blood pressure in anaesthetized dogs. Cranberries are a fruit chock full of vitamin C, and some people drink cranberry juice to help prevent urinary tract infections (UTI). Some of these medicine interactions can be risky. View abstract. Ashwagandha and Coumadin drug interactions - a phase IV clinical study of FDA data Summary: We study 132,077 people who take Ashwagandha or Coumadin. View abstract. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Yohimbe is the name of an evergreen tree that is found in some African countries. HHS Vulnerability Disclosure, Help Kava should not be used with alcohol or other drugs or herbs that can also cause liver toxicity. Sleep Med. Take extra care driving and doing tasks that you need to be alert for while taking this product. This is called a medicine interaction. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. There are also standardized extracts available. Indian J Exp Biol. Ask your doctor for advice about forms of ashwagandha and doses. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. Ashwagandha and Coumadin drug interactions - a phase IV - eHealthMe Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. It is important to remember that the best way to handle any possible drug interaction is to predict it and prevent it. metoprolol, nebivolol, propranolol), Diuretics (e.g. The Gale Encyclopedia of Alternative Medicine, third edition, 2009. PLoS.One. It is often used in generalized anxiety disorder. You can look up your blood thinner at https://www.drugbank.ca/drugs/DB06228 (that's the page for Rivaroxaban / Xarelto but you can search for your blood thinner at the top right). It seemed high to me too, when I asked for beta blockers, my doctor said he'd prescribe 40mg, to which I replied 'that seems a bit high, I read online that 10mg-20mg is effective for public speaking', but he just shook his head and said 'you wouldn't even be able to . FREE SHIPPING ON ORDERS $75 AND UP! Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Use of yohimbine with an MAOI may lead to increased blood pressure. Visit our Top 9 Ways to Prevent a Deadly Drug Interaction slideshow and join the Drugs.com Herbal Support Group to ask questions about drug interactions, check on the latest medical news, and provide your honest feedback, too. Acta Oncol. Bethesda, MD 20894, Web Policies While avoidance of medications in pregnancy is the best course of action, this is not Society tends to treat menopause as a disease; something to be avoided at all costs. Most importantly, what are the side effects of Ashwagandhato be aware of? Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. 2000 Jan 8;355(9198):134-8. doi: 10.1016/S0140-6736(99)06457-0. Because it can be affected by a large number of herbs, supplements and foods, it's important to consult your physician before taking any supplement with warfarin. 2019 Jan;35(Suppl 1):3-44. doi: 10.1007/s12055-019-00789-z. Can you get ashwagandha naturally from foods? Take extra care and check with your doctor if you have: Signs of a very bad reaction. Review on mechanisms and interactions in concomitant use of herbs and warfarin therapy. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. Some lab tests of cancer cells have found that ashwagandha might slow down their growth. sharing sensitive information, make sure youre on a federal Valerian has been used to treat insomnia and anxiety, and people often use it for this effect. Animal studies have found that ashwagandha could boost the effects of radiation therapy. It may cause you to become sleepy or drowsy. Despite these purported health benefits, there are some people who should not take ashwagandha. There are over 20 listed interactions with saw palmetto, but most of these are minor interactions. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. View abstract. All rights reserved. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Kumar S, Bouic PJ, Rosenkranz B. 1981;19(3):245-249. Some mixtures of medications can lead to serious and even fatal consequences. Antiplatelet drugs such as clopidogrel; NSAIDs such as ibuprofen; Blood thinners such as warfarin V. The effect of total alkaloids (ashwagandholine) on the central nervous system. Monitor your blood pressure closely. Am J Drug Alcohol Abuse 2009;35(1):1-11. Indian J Exp Biol. So truly speaking there may not any need of taking both ashw. View abstract. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Echinacea is also known as the American Cone Flower, Black Susan, or Purple Coneflower. It is based on ashwagandha and warfarin sodium (the active ingredients of Ashwagandha and Coumadin, respectively), and Ashwagandha and Coumadin (the brand names). Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Understanding Your Childs Life With ADHD, Think Your Child Has ADHD? It is estimated that about one-third of adults in the United States use herbal supplements.1 These supplements are widely used, especially by patients with chronic conditions. One study found that a compound containing ashwagandha helped relieve osteoarthritis symptoms. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Evid Based Complement Alternat Med. 1965;9(1):9-15. Of the total drug interactions, 129 are major, 500 are moderate, and 16 are minor. Potential interactions between alternatives therapies and warfarin. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. In some parts of the world, people eat ashwagandha shoots, seeds, and fruit. Can You Take A Z-Pak If You Have A Penicillin Allergy? Feverfew is a member of the daisy family. Ireland PJ, Hardy T, Burt AD, Donnelly MC. PMC View abstract. Ashwagandha is generally safe for most people when a high-quality supplement is used at responsible doses. View abstract. Cent.Nerv.Syst.Agents Med.Chem. Use birth control you can trust while taking this product. Last updated on July 14, 2022. Some herbs also interact with warfarin by reducing vitamin K synthesis by gut flora or by affecting enzymes involved in the vitamin K cycle; thus, pharmacodynamics play a major role in herbal and warfarin interaction mechanisms. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. For example. Select a condition to view a list of vitamins. Heck AM, Dewitt BA, Lukes AL. More are needed for more definitive results. View abstract. Concurrent use of Chinese herbal medicine and anticoagulants may reduce major bleeding events. There is no drug interaction reported. Some of the interactions between warfarin and medicinal herbs have been well assessed proving that they are closely-dependent. ALL PRODUCTS ARE DERIVED FROM HEMP AND CONTAINS LESS THAN 0.3% 9THC IN ACCORDANCE WITH THE 2018 FARM BILL. Answered by Dr. Brian Staiger, PharmD View abstract. The phase IV clinical study analyzes what interactions people who take Ashwagandha and Coumadin have. All rights reserved. 2002 Sep 2;164(36):4161-5. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. Follow-up and management of valvular heart disease patients with prosthetic valve: a clinical practice guideline for Indian scenario. Accessed Aug 1, 2022 at https://www.drugs.com/fda/kratom-mitragyna-speciosa-powder-products-gaia-ethnobotanical-recall-due-potential-salmonella-14176.html. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. 18 Herbal Supplements with Risky Drug Interactions - Drugs.com Is it safe to take Ashwagandha and Beta Blockers at the same - reddit Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Another way to take the two together is with capsules. Even though herbal supplements may be from plant or herb sources, the active ingredients can still be potent chemicals. A sampling of drugs you should not combine with St. John's Wort includes: There are many other possible interactions. Here, well cover all of the potential Ashwagandha side effects and what to do when they arise. Over 500 drug interactions exist with St. John's Wort and some can be dangerous. Black cohosh is a shrub-like plant found in North America. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. Anyone take Ashwagandha for stress while on blood thinners? These products are not intended to diagnose, treat, cure, or prevent any disease. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. 8600 Rockville Pike Ugeskr Laeger. 2020;72:28-36. The use of ginkgo extract dates back centuries in traditional Chinese medicine. Unable to load your collection due to an error, Unable to load your delegates due to an error. There is no standard dose of ashwagandha. It's important at least 14 days should elapse between discontinuation of MAOI therapy, an infrequently used treatment for depression, and initiation of treatment with yohimbine. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. 1998;20(1):191-198. In addition, central nervous system side effects of kava such as dizziness and drowsiness may be increased by alcohol. 1965;9(3):127-136. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Check other possible ginger-drug interactions here. Baker C, Kirby JB, O'Connor J, Lindsay KG, Hutchins A, Harris M. The perceived impact of ashwagandha on stress, sleep quality, energy, and mental clarity for college students: qualitative analysis of a double-blind randomized control trial. Kava, native to the South Pacific, is a member of the pepper family. Despite the lack of sufficient data to prove the safety and efficacy of these supplements, their use has increased greatly in elderly patients. View abstract. Indian J Psychol Med. all maps fatal bullet; who is running for senate in maryland 2022 But menopause can be positive. It is important to tell your doctor about all other medications you use, including vitamins and herbs. ConsumerLab.com uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. 7 min read, November 29, 2022 In order to do that, you need to be proactive in checking for possible drug interactions yourself in addition to asking your health care provider to screen for interactions. Examples of drugs that may interfere include: Call your doctor at once if you have signs of bleeding such as: swelling, pain, dizziness, weakness, bleeding gums, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, or any bleeding that will not stop. Be sure to talk with your doctor about this and all drugs you are taking, especially digoxin. In some cases, combining Ashwagandha with other substances, like certain prescription or over the counter drugs may cause them to be ineffective and could be unsafe. View abstract. View abstract. Two of the more serious interactions with goldenseal can occur with certain antipsychotic drugs. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Bjrnsson HK, Bjrnsson ES, Avula B, et al. Herbal supplements and prescription medicines Medicine (Baltimore). PLoS One 2009;4:e6628. ashwagandha and coumadin interaction - mail.ngosaurbharati.com Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Learn more about the possible counteractive effects of CoQ10 and blood thinners, including safety. 2020;34(5):1041-1059. Medically reviewed by Drugs.com. National Library of Medicine As a medication, Lexapro does have a list of other medicines where interaction is possible. What are the risks of taking ashwagandha? These are drugs like diazepam, lorazepam, phenobarbital, or zolpidem. Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. View abstract. We comply with the HONcode standard for trustworthy health information. View abstract. Do not use this product if you are pregnant or plan to become pregnant soon. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. Federal government websites often end in .gov or .mil. OTC Medication Use In Pregnancy: Wise or Worrisome? L-Theanine vs L-Tyrosine: Comparing Benefits, Side Effects & More, L-Theanine and Caffeine: The Nootropic Stack Your Mornings Need, Best Lions Mane Supplement: Everything to Consider. It is very widely utilized as a dietary supplement and used for a number of purported medical benefits, including: As ashwagandha is a botanical, it appears to have many different active components and a complex mechanism of action for how it works. 18 Herbal Supplements with Risky Drug Interactions. Yohimbine can dilate blood vessels and is often promoted for erectile dysfunction (ED) or sexual problems caused by some antidepressants like selective serotonin reuptake inhibitors (SSRI) antidepressants. Clipboard, Search History, and several other advanced features are temporarily unavailable. Ashwagandha is probably unsafe for pregnant women because it might increase the risk of miscarriage. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. Accessed Aug 1, 2022 at https://www.drugs.com/npp/. 2012;34(3):255-62. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Of the total drug interactions, 74 are major, 250 are moderate, and 2 are minor. Taking small doses - up to 250mg - of ashwagandha alongside your caffeine can help balance out the effects of both. 2005 - 2023 WebMD LLC. Given the risk of miscarriage, pregnant women should not useashwagandha. An interaction impacts how a drug works and might increase or reduce the effects of the said medicine. View abstract. If you are considering the use of any supplement, always check with your doctor first. More research is needed to understand how this may work, but Ashwagandha may be able to reduce cortisol levels to help balance blood pressure and heart rate. This product may cause you to be sleepy. Phytother Res. Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Mushroom tea is super simple. Recognition of the adverse effects of medicinal herbs is not routine and the reports on such effects are even less frequent in clinical practice. Cureus. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. In most cases, Ashwagandha has shown to have little to no risk of adverse effects. Ashwagandha might increase how much thyroid hormone the body produces. The use of herbal supplements is becoming a major safety concern because drugherbal interactions can cause serious adverse events. View abstract. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. J Ethnopharmacol 1999;67:233-39. Int Ayurvedic Med J 2013;1(5):1-7. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. Although several herbs have been proven to alter the mechanism of warfarin, there are not enough clinical trial data to prove the significance of those effects. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. There are many conditions garlic has been promoted for: to reduce cholesterol and triglycerides, to prevent cancer, to lower blood sugar levels, and to reduce menstrual pain, among other uses. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. I felt almost godlike with how comfortable I was at the podium. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. To prevent unnecessary adverse drug interactions, health care professionals need to be proactive in caring for their patients. 2020;12(2):e7083. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Most clinical research supports valerian's use to relieve insomnia and improve sleep quality. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. St. Johns Wort is a popular herbal supplement widely used to help with symptoms of depression. Side effects like respiratory distress, profound sedation, coma, and even death may occur. J Ethnopharmacol 1999;67:27-35. There are many different types of choline supplements, but Alpha-GPC may just be superior. Signs of a very bad reaction. The use of herbal supplements has a long history - dating back thousands of years. The FDA can and does seize and remove from the market tainted, contaminated, fraudulent or unsafe dietary supplements when they are aware of problems. selective serotonin reuptake inhibitors (SSRIs), slow down the absorption of iron from your body, Top 9 Ways to Prevent a Deadly Drug Interaction. J Clin Psychiatry. Vomiting and nausea. View abstract. There are over 260 drug interactions with kava, and some of them are serious. Samuels N. Herbal remedies and anticoagulant therapy. ashwagandha and coumadin interaction. Supplements that may increase warfarin's blood-thinning effect (and consequently, the risk of abnormal bleeding) include: Supplements that may reduce warfarin's ability to thin the blood include: Join now to add comments and get all member benefits, including over 1,300 reviews. Indian J Pharmacol. and transmitted securely. Thankfully, not all people experience this side effect, and taking Ashwagandha at night can help to manage these possible effects. 2011;68(1):3-8. View abstract. Go to the ER right away. View abstract. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Warfarin interaction with Matricaria chamomilla - PubMed Costache II, Miron A, Hncianu M, Aursulesei V, Costache AD, Aprotosoaie AC. Ashwagandha can increase the activity of the immune system. J Clin Med 2021;10(16):3644. Because of this, herbal supplements can have drug interactions, even with each other or with food or alcohol. View abstract. J Med Food 2022. Hsu SM, Lin HJ, Kao YW, Li TM, Shia BC, Huang ST. PLoS One. . National Institute of Health (NIH). The case reports with severe adverse effects such as spontaneous postoperative bleeding, formation of hematomas, hematemesis, melena, thrombosis, subarachnoid hemorrhage and/or subdural hematomas after concomitant use of warfarin and the medicinal herbs: Panax ginseng, Hypericum perforatum, Salvia milthiorizza, Gingko biloba, Serenoa repens, Angelica sinensis, Vaccinium species, Allium sativum, Zingiber officinale, Tanacetum parthenium, Lucium barbarum, Matricaria chamomilla, Boswellia serrata and Camellia sinensis have been estimated. Ashwagandha side effects While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. The use of the eHealthMe site and its content is at your own risk. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. These events are due to a lack of patient education and information about drug interactions involving alternative medicines. Symptoms of an allergic reaction to Ashwagandha may include: In some cases, herbal remedies can interact with certain medications, including other supplements and OTC and prescription drugs. Role of an indigenous drug Geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Large amounts of vitamin K may interfere with the activity of some. In a review article published in March 2014, 38 herbs were reviewed and were found to clinically interact with warfarin. While usually well-tolerated, important drug interactions can occur. Anbalagan, K. and Sadique, J. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Tumori 8-31-1994;80(4):306-308. For example, kratom is one example that has been involved in many seizures. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Safe For Diabetics? Enter other medications to view a detailed report. Ashwagandha might lower blood pressure. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Symptoms of an allergic reaction to Ashwagandha may include: Swelling of the lips, mouth, and airways Difficulty breathing Skin rashes or hives Runny nose Watery eyes Nausea and vomiting Stomach cramping Bloating Loose stools Interactions With Other Supplements or Medications Garlic has been rarely reported to affect blood clotting and may affect people who take, Patients should be advised to limit their consumption of green tea and green tea extracts during treatment with lisinopril, as these products may lower blood levels of the ACE inhibitor, Dried green tea leaves contain vitamin K, which can increase blood clotting. Warfarin sodium and Maca maca drug interactions - eHealthMe Yes, the effectiveness of warfarin (Coumadin), anisindione (Miradon) and other anticoagulant drugs prescribed to help prevent blood clots can be impacted by taking supplements. 2001;75(2-3):165-168. This information may not fit your specific health circumstances. Liver Int. Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, Duan W, Koh HL, Zhou S. Drugs. There is no drug interaction reported. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. Information on laxative interactions with other medications and supplements such as Maalox, antibiotics, and statins and diabetes medications. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. If saw palmetto is combined with estrogens or oral contraceptives, the effectiveness of the hormonal therapies could be reduced. Of course, theres more to the story that needs to be considered before adding a new supplement to your daily wellness routine. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. You can check other yohimbine interactions here. FOIA Ginseng has been used in Asian countries for its therapeutic effects for centuries. Seek immediate medical attention if you experience any signs and symptoms of bleeding such as: Learn More: Melatonin: Worth Losing Sleep Over? Keep out of reach of children. Dosage of drugs is not considered in the study. View abstract. Herb-drug interactions: a literature review. Some evidence suggests that Ashwagandha may help you sleep better at night, but daytime drowsiness may be an inconvenience for some people. We comply with the HONcode standard for trustworthy health information. Are Oral Rehydration Products Like Liquid I.V. View abstract. 5 min read, November 29, 2022 8-16-1995;95(1-2):189-193. J Ethnopharmacol 1998;62:209-14. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Can You Take Ashwagandha And Orilissa Together? 2020;12(4):1119. Still, best to proceed with caution. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs.